L'importanza della melatonina, tramite effetto ed interazione sui mitocondri, nei disturbi dell'umore e nella schizofrenia

Considerando che la melatonina ha un effetto regolatore sul ritmo circadiano e sulla la qualità del sonno, essa ha una stretta interazione sui disturbi dell'umore e la schizofrenia. In questa raccolta di studi si è cercato di riassumere gli effetti della melatonina sull'attività mitocondriale nei pazienti affetti da schizofrenia e disturbi dell'umore.

The importance of melatonin and mitochondria interaction in mood disorders and schizophrenia: A current assessment.

Curr Med Chem. 2016 Apr 27;

Authors: Uğuz AC, Demirci K, Palma JE

Abstract
Mitochondria play have a critical role in regulating cellular functions, such as redox signaling, calcium homeostasis, and apoptosis. Also, mitochondria are crucial for neurogenesis and neuronal functions. Melatonin is an indole analog hormone, which is generally produced by the pineal gland. It plays a vital role in circadian rhythm and act as a powerful antioxidant by scavenging free radicals, immunomodulators, and anticancer agents. Schizophrenia and mood disorders are the two major psychiatric disorders. Disturbances of sleep and circadian rhythms are well-known symptoms of schizophrenia and mood disorders (bipolar disorder, major depression). Since melatonin has a regulator effect on circadian rhythm and sleep quality, it has a close interaction with between schizophrenia and mood disorders. Herein, we aimed to summarize the effects of melatonin on mitochondrial activity in schizophrenia and mood disorders.

PMID: 27121187 [PubMed - as supplied by publisher]