La melatonina ha un ruolo di prevenzione della steatoepatite e può migliorare i risultati dei trapianti di fegato

In questa review curata dell'università di Zaragoza in collaborazione con University of Texas Health Science Center at San Antonio, è stata evidenziata l'efficacia della melatonina sia nella prevenzione della steopatite sia nel migliorare l'esito del trapianto di organi, riducendo i danni da ischemia-riperfusione grazie al suo effetto sinergico con i liquidi di conservazione degli organi. La steatosi epatica non alcolica (Nafld) e steatoepatite non alcolica (Nash) sono la causa di disturbi epatici severi in tutto il mondo.

Melatonin role preventing steatohepatitis and improving liver transplantation results.
Cell Mol Life Sci. 2016 Mar 29;
Authors: Esteban-Zubero E, García-Gil FA, López-Pingarrón L, Alatorre-Jiménez MA, Ramírez JM, Tan DX, García JJ, Reiter RJ

Abstract
Liver steatosis is a prevalent process that is induced due to alcoholic or non-alcoholic intake. During the course of these diseases, the generation of reactive oxygen species, followed by molecular damage to lipids, protein and DMA occurs generating organ cell death. Transplantation is the last-resort treatment for the end stage of both acute and chronic hepatic diseases, but its success depends on ability to control ischemia-reperfusion injury, preservation fluids used, and graft quality. Melatonin is a powerful endogenous antioxidant produced by the pineal gland and a variety of other because of its efficacy in organs; melatonin has been investigated to improve the outcome of organ transplantation by reducing ischemia-reperfusion injury and due to its synergic effect with organ preservation fluids. Moreover, this indolamine also prevent liver steatosis. That is important because this disease may evolve leading to an organ transplantation. This review summarizes the observations related to melatonin beneficial actions in organ transplantation and ischemic-reperfusion models.

PMID: 27022943 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/27022943?dopt=Abstract