Ridurre la frequenza degli attacchi di cefalea con la melatonina



Studio pilota per il trattamento di cefalea con melatonina. L' obiettivo dello studio, realizzato dall'università di Atene, era quello di valutare la potenziale efficacia della melatonina per la prevenzione cefalea primaria. I risultati ottenuti tramite l'assunzione di 4 mg di melatonina, 30 minuti prima di andare a letto per sei mesi, sono stati significativi in quanto si è verificata una riduzione statisticamente significativa della frequenza della cefale nei pazienti coinvolti nello studio.

Melatonin 4 mg as prophylactic therapy for primary headaches: a pilot study.

Funct Neurol. 2016 Jan-Mar;31(1):33-7
Authors: Bougea A, Spantideas N, Lyras V, Avramidis T, Thomaidis T

Abstract
There is growing evidence that headaches are connected to melatonin secretion. Our aim was to assess the potential effectiveness of melatonin for primary headache prevention. Forty-nine patients (37 with migraine and 12 with chronic tension-type headache, TTH) were prescribed oral melatonin, 4 mg, 30 minutes before bedtime for six months. Forty-one (83.6%) of the 49 patients completed the study, while eight dropped out for personal reasons. A statistically significant reduction in headache frequency was found between baseline and final follow-up after six months of treatment (p=0.033 for TTH patients and p<0.001 for migraineurs). The Headache Impact Test score was significantly reduced in both groups of headache patients (p=0.002 and p<0.001, respectively). At baseline, melatonin levels, measured both during a headache attack and a pain-free period, did not differ between patients with TTH and migraineurs (p=0.539 and p=0.693, respectively), and no statistically significant differences in Hamilton Depression Rating Scale scores were found between the two groups. Melatonin 4 mg as prophylactic therapy for primary headaches: a pilot study This pilot study shows promising results, in terms of headache frequency reduction and daily quality of life improvement, in both groups.

PMID: 27027892 [PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/27027892?dopt=Abstract

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