11 FEB - Le persone che dormono meno di 6 ore a notte hanno quasi il 50 per cento di rischio in più di sviluppare adenomi del colon retto rispetto a quanti dormono soltanto un’ora in più. Lo rivela uno studio pubblicato nel numero in stampa della rivista Cancer.
Da tempo è stata rilevata un’associazione tra carenza di sonno e un aumentato rischio di andare incontro a obesità, malattie cardiache o diabete, ma mai era stato notato un nesso con una qualche forma tumorale.
“Da quel che ne sappiamo è il primo studio a rilevare un’associazione significativa tra durata del sonno e adenomi del colon-retto”, ha commentato il primo firmatario dello studio Li Li della Case Western Reserve University School of Medicine di Cleveland (Usa). “La carenza di sonno può adesso essere vista come un nuovo fattore di rischio per lo sviluppo del cancro del colon”.
Lo studio, che è stato finanziato indirettamente dal National Cancer Institute americano, è stato condotto somministrando un questionario teso a verificare la durata e la qualità del sonno a quasi 1300 pazienti che stavano per sottoporsi a una colonscopia.
Sono stati individuati adenomi in 338 di questi. E tra quanti erano risultati positivi era particolarmente elevata la presenza di persone che dichiaravano di dormire meno di sei ore a notte.
L’associazione, inoltre, non scompariva se i dati venivano “ripuliti” da altri fattori che avrebbero potuto aumentare il rischio di cancro al colon, come l’essere fumatore, avere familiarità per cancro o un indice di massa corporea elevato.
L’aumento di rischio, inoltre, non è irrilevante: circa il 50 per cento, analogo a quello causato da un parente con lo stesso tumore o da un eccessivo consumo di carni rosse.
Alla luce di questi dati, ha affermato Li, “l’insufficiente durata del sonno sta diventando un problema di sanità pubblica, che causa non soltanto obesità, diabete e malattie coronariche, ma anche - come rivela il nostro studio - adenomi. Interventi che mirino ad aumentare la durata del sonno e la sua qualità potrebbero essere una strada finora sottovalutata per prevenire il cancro al colon”.
Restano un mistero le ragioni della correlazione tra sonno e cancro. I ricercatori hanno azzardato diverse teorie, come i livelli di melatonina o l’insulinoresistenza più frequente in chi dorme poco, ma servono ulteriori studi che confermino questi dati e ne diano un’interpretazione.
Firstly, in the war against cancer , including colon cancer, of course, we must remember that not all individuals are born equal!
Secondly, based on my 55-year-long, well-established, clinical experience, regarding the war against whatever cancer we have necessarily to study somethingh that allows all doctors at the bedside, i.e. clinically, to recognize in apparently healthy individuals not only environmental risk factors (hyperinsulinemia-insulinresistance, melatonine deficiency, metabolic disorders, a.s.o.), which either bring about or aggravate chromosomal alterations, as those observed in cancer cells.
In fact, our goal can be reached hopefully only if doctors are able to ascertain, or at least suspect, at the bed-side in apparently health persons chromosomal alterations, decade before cancer on-set (1-3).
As a working hypothesis, I thought previously that all chromosomal alterations of whatever nature, are necessarily acccompanied with similar microvascular modification of the local microcirculatory bed, both structural and functional in nature, on the base of a singular, functional mitochondrial disorder, I have termed Congenital Acidosic Enzyme-Metabolic Histngiopathy (2-10). As a matter of fact, both genetical and environmental factors induce contemporaneously parenchymal and microvascular cells alterations, according to the well-known concept of Tiscedorf’s Angiobiotopie. For instance, a family of molecules called cyclins was descovered. It is through changes in the production of cyclins during the cell cycle that the activity of the genes controlling it are themselves regulated. All these events (control, regulation a.s.o.), however, can happen only by means of changes in local microcirculation (so-called microcirculatory remodelling). Thanks to Quantum Biophysical Semeiotics , we can bedside evaluate microcirculatory bed clinically structure and function in a precise manner (2-5).
In my opinion, the decline in cancer rates all over the world could be more intense if scientists will think over and discuss, fortunately, the possibility that exists the Oncological Terrain-Dependent Inherited Real Risk and its efficacious treatment (9, 10). As a matter of fact, e.g. not all smokers are involved by pulmonary cancer, as well as not all people with chronic hepatitis will die of hepatocarcinoma. On the other side, in some families malignancies occur more frequently than in others. Actually, as I described in the above-mentioned papers, there are other causes that accounts for the reason of existence of the oncological real risk, i.e. oncological terrain.
Surely there is a strict relation between sleepness and cancer, whose real nature I have illustrated in a recent article, on the light of Oncological Terrain (11).
At this point, the first question is the following: What does characterize oncological terrain from the clinical point of view? In fact, in order to achieve efficacious cancer prevention on very large scale it is unavoidable that the modifications occurring in the biological controll system could be easily, promptly, and quantitatively ascertained and properly evaluated with the aid of a clinical method, i.e. by the use of a sthetoscope, and certainly without application of sophysticated semeiotics, that does not apply in all individuals, and, moreover, only a few doctors can utilize them.
If it is possible to answer this first question, a second one immediately follows: The oncological terrain which certanly can be induced, is also in some way reversible? It is urgent and necessary to know if the oncological terrain can be reversed, i.e. if it can totally or greatly disappeare, with the aid of histangioprotective drugs (in my eperience Melatonine , and Cellfood proved to be very efficacious in ameliorating mitochondrial respiratory chain function) and obviously diet, ethymologically speaking, which exert a favourable influence on the characteristic modifications of the psicho-neuro-endocrine- immunological system, that represent Oncological Terrain (2-11).
The war against cancer, including colon cancer, will be fortunately won if all doctors are going to learn how recognize, with the aid of a stethoscope, individuals apparently healthy, but positive for Oncological Terrain-Dependent Inherited Real Risk of cancer, present in a well defined tissue region, wherein malignancy “can” occur. These subject, rationalized enrolled in oncological Primary Prevention have to undergo immediately to proper diet, ethymologically speaking, and drugs, cited above.
Unfortunately, change in Medicine is an up-hill task! Moreover, in the discussion between theories the power of the antagonists is more important than that of the ideas. But, fortunately, ideas go on and on, and on.
1) Watts G. Three cell cycle scientists win Nobel prize. BMJ 2001; 323:823 (13 October).
2) Stagnaro-Neri M., Stagnaro S., Semeiotica Biofisica del torace, della circolazione ematica e della anticorpopoiesi acuta e cronica. Acta Med. Medit. 13, 25 1997
3) Stagnaro-Neri M., Stagnaro S., Semeiotica Biofisica: la manovra di Ferrero-Marigo nella diagnosi clinica della iperinsulinemia-insulino resistenza. Acta Med. Medit. 13, 125 1997
4) Stagnaro-Neri M., Stagnaro S., Semeiotica Biofisica: valutazione clinica del picco precoce della secrezione insulinica di base e dopo stimolazione tiroidea, surrenalica, con glucagone endogeno e dopo attivazione del sistema renina-angiotesina circolante e tessutale Acta Med. Medit. 13, 99.
5) Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeiotica Biofisica. Il Terreno Oncologico. Ed. Travel Factory, Roma, 2004. http://www.travelfactory.it
6) Stagnaro S., Stagnaro-Neri M., Le Costituzioni Semeiotico-Biofisiche.Strumento clinico fondamentale per la prevenzione primaria e la definizione della Single Patient Based Medicine. Ed. Travel Factory, Roma, 2004. http://www.travelfactory.it/
7) Simone Caramel and Sergio Stagnaro (2011)Quantum Biophysical Semeiotics and mit-Genome's fractal dimension Journal of Quantum Biophysical Semeiotics, 1 1-27,
http://www.sisbq.org/uploads/5/6/8/7/5687930/joqbs_mitgenome.pdf
8) Stagnaro S. Oncological terrain plays a paramount role in the war against gastric cancer. http://www.biomedcentral.com/1471- 230X/4/28/comments#87454
9) Stagnaro S., Stagnaro-Neri M., La Melatonina nella Terapia del Terreno Oncologico e del Reale Rischio Oncologico. Ediz. Travel Factory, Roma, 2004.
10) Stagnaro Sergio. Reale Rischio Semeiotico Biofisico. I Dispositivi Endoarteriolari di Blocco neoformati, patologici, tipo I, sottotipo a) oncologico, e b) aspecifico. Ediz. Travel Factory, www.travelfactory.it, Roma, Luglio 2009.
11) Stagnaro Sergio. Insomnia is a Sign of Di Bella's Oncological Terrain. www.sisbq.com, 1, February, 2011. http://www.sisbq.org/uploads/5/6/8/7/5687930/insomniacancer.pdf ; http://www.sci-vox.com/. http://www.sci-vox.com/stories/story/2011-02-04di+bella%27s+oncological+terrain+and+insomnia..html ; http://stagnaro.wordpress.com/2011/02/04/insomnia-as-sign-of-di-bellas-oncological-terrain/ ; http://sciphu.com/2011/02/di-bellas-oncological-terrain-and.html
12) Stagnaro S., Stagnaro-Neri M., Oncological Terrain, conditio sine qua non of Oncogenesis, 2004: http://www.gutjnl.com/cgi/eletters?lookup=by_date&days=60
13) Stagnaro Sergio. "Genes, Oncological Terrain, and Breast Cancer" World Journal of Surgical Oncology., 2005, http://www.wjso.com/content/3/1/45/comments#205475
14) Sergio Stagnaro. Mitochondrial Genome of the Mastodon highlights Human Constitutions. PLOS Biology, (01 August 2007) http://biology.plosjournals.org/perlserv/?request=read-response&doi=10.1371/journal.pbio.0050207#r1725
15) Stagnaro Sergio.Cancer Risk Factors and Oncological Terrain. 2006. http://www.wjso.com/content/4/1/74/comments#247528
16) Stagnaro Sergio. ColonCancer Oncological Terrain-Dependent Inherited Real Risk. Ann. Int. Med. (15 April 2009), http://www.annals.org/cgi/eletters/150/7/465