Role of melatonin in Alzheimer-like neurodegeneration1



Jian-zhi WANG2,4, Ze-fen WANG2,3
2Pathophysiology Department, Key Laboratory of Neurological Diseases of Hubei Province, Tongji Medical School, Huazhong University of
Science and Technology, Wuhan 430030, China; 3Department of Physiology, Medical College, Wuhan University, Wuhan 430071, China


ABSTRACT

Alzheimer disease (AD), an age-related neurodegenerative disorder with progressive loss of memory and deterioration of comprehensive cognition, is characterized by extracellular senile plaques of aggregated B-amyloid (AB), and intracellular neurofibrillary tangles that contain hyperphosphorylated tau protein. Recent studies showed that melatonin, an indoleamine secreted by the pineal gland, may play an important role in aging and AD as an antioxidant and neuroprotector.

Melatonin decreases during aging and patients with AD have a more profound reduction in this hormone. Data from clinical trials indicate that melatonin supplementation improves sleep, ameliorates sundowning, and slows down the progression of cognitive impairment in alzheimer’s patients. Melatonin efficiently protects neuronal cells from AB-mediated toxicity via antioxidant and anti-amyloid properties: it not only inhibits AB generation, but also arrests the formation of amyloid fibrils by a structure-dependent interaction with AB. Our recent studies have demonstrated that melatonin efficiently attenuates Alzheimer-like tau hyperphosphorylation. Although the exact mechanism is still not fully understood, a direct regulatory influence of melatonin on the activities of protein kinases and protein phosphatases is proposed. Additionally, melatonin also plays a role in protecting cholinergic neurons and in anti-inflammation. Here, the neuroprotective effects of melatonin and the underlying mechanisms by which it exerts its effects are reviewed. The capacity of melatonin to prevent or ameliorate tau and AB pathology further enhances its potential in the prevention or treatment of AD.



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